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Effect of inhibition of Dlx3 on gene expression alteration during alveolar bone healing

GSE270089 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/06/01 Platform GPL23479
Summary
The alveolar ridge loss and absorption strongly affects the following implantation and prosthodontic treatment. It is a clinical challenge and research hotspot to sustain the alveolar bone mass. Interestingly, the patients affected with Tricho-dento-osseous (TDO) syndrome present high density of skull and jaw bones, and can remain sufficient bone mass after tooth extraction in a long time. The mechanism of this phenomenon is of highly study value. To explore DLX3-the disease-causing gene of TDO syndrome, we constructed the mouse alveolar loss and healing model. After tooth extraction, gelatin sponge with GFP or with adenovirus vector that can suppress the expression of Dlx3 gene was put in normal murine alveolar socket, respectively. RNA sequencing of the alveolar bone of these two groups was performed to explore the downstream molecular alterations.
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Direct links to NCBI, no account and no request form: the whole study as GSE270089_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1124972 and SRA study SRP514497. Searching any of these in the dataset finder brings you back here.

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