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Deciphering NEUROD1's target genes and miRNAs: an integrative analysis in small cell lung cancer

GSE270263 Homo sapiens Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing 8 samples Submitted 2025/06/28 Platform GPL24676
Summary
Small cell lung cancer (SCLC) is a particularly challenging tumor to treat, due to its poor prognosis. ASCL1 and NEUROD1 are master regulators that define the molecular subtypes of SCLC, which are characterized by neuroendocrine features. Immunohistochemical studies have demonstrated that these genes can be co-expressed to varying degrees. While the transcriptional functions of ASCL1 have been well-documented, those of NEUROD1, specifically its target genes and miRNAs, remain less explored. The objective of this study was to identify the targets of this gene.
Published in
Integrative epigenome and transcriptome analyses reveal transcriptional programs differentially regulated by ASCL1 and NEUROD1 in small cell lung cancer
Takumida H, Saito A, Okabe Y et al. · Oncogene 2025 · PMID 40595415 · doi:10.1038/s41388-025-03481-2
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Also filed as BioProject PRJNA1125899 and SRA study SRP514870. Searching any of these in the dataset finder brings you back here.

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