← BioTransfer GEO Dataset Finder
GEO series

Tau accumulation induces microglial state alterations in Alzheimer’s disease model mice (snRNA-seq, part 2)

GSE270386 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/16 Platform GPL24247
Summary
Unique microglial states have been identified in Alzheimer’s disease (AD) model mice and postmortem AD brains. Although it has been well documented that amyloid-β accumulation induces the alteration of microglial states, the relationship between tau pathology and microglial states remains incompletely understood because of a lack of suitable AD models. In the present study, we generated a novel AD model mouse by the intracerebral administration of tau purified from human brains with primary age-related tauopathy into AppNL-G-F/MAPT double knock-in (dKI) mice.
Published in
Tau Accumulation Induces Microglial State Alterations in Alzheimer's Disease Model Mice
Nagata K, Hashimoto S, Joho D et al. · eNeuro 2024 · PMID 39592224 · doi:10.1523/ENEURO.0260-24.2024
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE270386_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1126290 and SRA study SRP515077. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.