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The Role of Orphan GPCR GPR153 in Regulating Vascular Damage Responses

GSE270457 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/06/04 Platform GPL30173
Summary
Expression of GPR153 is upregulated in response to damage both in smooth muscle cells and endothelial cells.We found knockdown of GPR153 in SMC reduced the ligation-induced neointima formation, and GPR153 defeciency in EC protect the mice from neuroinflammation. The mechanism of orphan GPCR GPR153 in regulating cell signaling were studied in SMC, EC and HEK293t cell lines.
Published in
Orphan receptor GPR153 facilitates vascular damage responses by modulating cAMP levels, YAP/TAZ signaling, and NF-κB activation
Shao J, Kwon J, Wang T et al. · Nature communications 2025 · PMID 40623996 · doi:10.1038/s41467-025-61057-w
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Also filed as BioProject PRJNA1126670 and SRA study SRP515348. Searching any of these in the dataset finder brings you back here.

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