GEO series
Antigen-driven CD8+ T cell clonal expansion is a prominent feature of MASH in humans and mice [human]
GSE270488
Homo sapiens
Expression profiling by high throughput sequencing; Other
18 samples
2025/01/22
GPL24676
Summary
Metabolic dysfunction-associated steatoheptaitis (MASH) is a chronic liver disease caused by prolonged poor diet. During MASH-induced chirrosis in humans and diet-induced MASH in murine models, T cells accumulated in the liver but their function in MASH is unresolved. We aimed to evaluated differences in T cell phenotype and T cell receptor (TCR) repertoire in T cells from the livers of diseased humans and murine models. This set contains human sequencing data.
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Paper (PMID 39047085) ↗
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