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Epigenetic heterogeneity and state-specific transcriptional programs determine differential drug response in osteosarcoma.

GSE270506 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 279 samples Submitted 2025/09/29 Platform GPL18573Platform GPL24676Platform GPL34281Platform GPL20301
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 279 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Topic
OsteosarcomaThis series is part of our curated briefing on it.
Samples
279 samples: 101 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
This dataset
Open GSE270506 in finder → Find more human RNA-seq datasets → Osteosarcoma landscape →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270506_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1126817 and SRA study SRP515377. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗
Study design
101 conditions, mostly in duplicate
OS833_IgG_NONE ×8 OS774_IgG_NONE ×6 OS833_K27Ac_NONE ×6 OS742_IgG ×5 OS742_H3K27Ac ×5 OS742_K27Ac_NONE ×5 Patient derived Xenograph_PDX ×3 OS152_IgG ×3 +128 more

Supports a between-group comparison across 244 samples.

How we read this: 101 replicated groups read from 279 sample titles; they account for 244 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 239 more — browse all 279 samples with per-sample file links →

More Osteosarcoma datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.