Chromatin distribution alterations of histone modifacations and PRC2 complex caused by Rack7 deletion in primary astrocyte [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 24 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- RACK7 Interacts with PRC2 Complex to Regulate Astrocyte DevelopmentAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270581_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1127522 and SRA study SRP515896. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8347691 WT, RACK7, input
- GSM8347692 RKO, RACK7, input
- GSM8347693 WT, RACK7, ChIP
- GSM8347694 RKO, RACK7, ChIP
- GSM8347695 WT, K4me1/3, K27ac, input
- GSM8347696 RKO, K4me1/3, K27ac, input
- GSM8347697 WT,H3K4me1,ChIP
- GSM8347698 WT,H3K4me3,ChIP
- GSM8347699 WT,H3K27ac,ChIP
- GSM8347700 RKO,H3K4me1,ChIP
- GSM8347701 RKO,H3K4me3,ChIP
- GSM8347702 RKO,H3K27ac,ChIP
- GSM8347703 WT,H3K27me3, input
- GSM8347704 RKO,H3K27me3,input
- GSM8347705 WT,H3K27me3,ChIP
- GSM8347706 RKO,H3K27me3,ChIP
- GSM8347707 WT, PRC2, input
- GSM8347708 RKO, PRC2, input
- GSM8347709 WT,EZH2,ChIP
- GSM8347710 WT,EED,ChIP
- GSM8347711 WT,SUZ12,ChIP
- GSM8347712 RKO,EZH2,ChIP
- GSM8347713 RKO,EED,ChIP
- GSM8347714 RKO,SUZ12,ChIP
- GSE270582 Effects of deletion Rack7 on gene expression in primary astrocyte during mouse postnatal development [RNA-Seq] 12 samples shares rack7, astrocyte, deletion
- GSE289642 Noncanonical PRC2 chromatin association reveals a key role of EZHIP in intergenerational epigenetic memory transition [ChIP-Seq, Cut & Run] 107 samples shares prc2, chromatin
- GSE264672 EPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization (ChIP-Seq) 32 samples shares prc2, chromatin
- GSE55697 Deletion of RING1A/B and loss of H2AK119ub1 affects PRC2 occupancy and H3K27me3 genome-wide 18 samples shares prc2, deletion
- GSE288574 Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets [ChIP-Seq] 17 samples shares prc2, alterations
- GSE263937 Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion [Cut & Run] 14 samples shares prc2, chromatin
- GSE289641 Noncanonical PRC2 chromatin association reveals a key role of EZHIP in intergenerational epigenetic memory transition [RNA-Seq] 68 samples shares prc2, chromatin
- GSE289856 Convergence of aging- and rejuvenation-related epigenetic alterations on PRC2 targets 39 samples shares prc2, alterations
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.