GEO series

Characterisation of the regulatory landscape in Crohn’s disease reveals miRNA-associated alterations that shape anti-TNF response

GSE270663 Homo sapiens (human) Non-coding RNA profiling 238 samples Submitted 2025/07/16 Platform GPL24676

At a glance

Non-coding RNA profiling · human · 238 samples

What it is: Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
Organism: Homo sapiens (human)
Samples: 238 samples: 119 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper: Characterization of the Regulatory Landscape in Crohn's Disease Reveals microRNA-Associated Alterations that Shape Anti-TNF ResponseInflammatory bowel diseases · 2025

SuperSeries — this record groups several sub-series.

Summary (written by the submitters)

This SuperSeries is composed of the SubSeries listed below.

Published in

Characterization of the Regulatory Landscape in Crohn's Disease Reveals microRNA-Associated Alterations that Shape Anti-TNF Response

Cervera-Seco L, Baldán-Martín M, Fernández-Tomé S et al. · Inflammatory bowel diseases 2025 · PMID 40067082 · doi:10.1093/ibd/izaf029

This dataset

Open GSE270663 in finder → Find more human RNA-seq datasets →

Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270663_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

Also filed as BioProject PRJNA1127645 and SRA study SRP515699. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40067082) ↗

Study design

119 conditions, mostly in duplicate

Healthy control-1, terminal ileum, basal ×2 Healthy control-1, terminal ileum, infliximab ×2 Healthy control-1, left colon, basal ×2 Healthy control-1, left colon, infliximab ×2 Healthy control-2, terminal ileum, basal ×2 Healthy control-2, terminal ileum, infliximab ×2 Healthy control-2, left colon, basal ×2 Healthy control-2, left colon, infliximab ×2 +111 more

Supports a case/control comparison: 158 samples read as cases, 80 as controls.

How we read this: 119 replicated groups read from 238 sample titles; they account for 238 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

GSM8349488 Healthy control-1, terminal ileum, basal Healthy control-1, term…
GSM8349489 Healthy control-1, terminal ileum, infliximab Healthy control-1, term…
GSM8349490 Healthy control-1, left colon, basal Healthy control-1, left…
GSM8349491 Healthy control-1, left colon, infliximab Healthy control-1, left…
GSM8349492 Healthy control-2, terminal ileum, basal Healthy control-2, term…
GSM8349493 Healthy control-2, terminal ileum, infliximab Healthy control-2, term…
GSM8349494 Healthy control-2, left colon, basal Healthy control-2, left…
GSM8349495 Healthy control-2, left colon, infliximab Healthy control-2, left…
GSM8349497 Healthy control-3, terminal ileum, basal Healthy control-3, term…
GSM8349500 Healthy control-3, terminal ileum, infliximab Healthy control-3, term…
GSM8349502 Healthy control-3, left colon, basal Healthy control-3, left…
GSM8349503 Healthy control-3, left colon, infliximab Healthy control-3, left…
GSM8349504 Healthy control-4, terminal ileum, basal Healthy control-4, term…
GSM8349505 Healthy control-4, terminal ileum, infliximab Healthy control-4, term…
GSM8349506 Healthy control-4, left colon, basal Healthy control-4, left…
GSM8349507 Healthy control-4, left colon, infliximab Healthy control-4, left…
GSM8349508 Healthy control-5, terminal ileum, basal Healthy control-5, term…
GSM8349509 Healthy control-5, terminal ileum, infliximab Healthy control-5, term…
GSM8349510 Healthy control-5, left colon, basal Healthy control-5, left…
GSM8349511 Healthy control-5, left colon, infliximab Healthy control-5, left…
GSM8349512 Healthy control-6, terminal ileum, basal Healthy control-6, term…
GSM8349513 Healthy control-6, terminal ileum, infliximab Healthy control-6, term…
GSM8349514 Healthy control-6, left colon, basal Healthy control-6, left…
GSM8349515 Healthy control-6, left colon, infliximab Healthy control-6, left…
GSM8349516 Healthy control-7, terminal ileum, basal Healthy control-7, term…
GSM8349517 Healthy control-7, terminal ileum, infliximab Healthy control-7, term…
GSM8349518 Healthy control-7, left colon, basal Healthy control-7, left…
GSM8349519 Healthy control-7, left colon, infliximab Healthy control-7, left…
GSM8349520 Healthy control-8, terminal ileum, basal Healthy control-8, term…
GSM8349521 Healthy control-8, terminal ileum, infliximab Healthy control-8, term…
GSM8349522 Healthy control-8, left colon, basal Healthy control-8, left…
GSM8349523 Healthy control-8, left colon, infliximab Healthy control-8, left…
GSM8349524 Healthy control-9, terminal ileum, basal Healthy control-9, term…
GSM8349525 Healthy control-9, terminal ileum, infliximab Healthy control-9, term…
GSM8349526 Healthy control-9, left colon, basal Healthy control-9, left…
GSM8349527 Healthy control-9, left colon, infliximab Healthy control-9, left…
GSM8349528 Healthy control-10, terminal ileum, basal Healthy control-10, ter…
GSM8349529 Healthy control-10, terminal ileum, infliximab Healthy control-10, ter…
GSM8349530 Healthy control-10, left colon, basal Healthy control-10, lef…
GSM8349531 Healthy control-10, left colon, infliximab Healthy control-10, lef…

+ 198 more — browse all 238 samples with per-sample file links →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.