Gene expression profile of liver obtained from liver-specific Me1-deficient mice challenged with high-fat diet
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 10 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270742_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1128104 and SRA study SRP516047. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 10 sample titles: 10 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8351238 21
- GSM8351239 30
- GSM8351240 54
- GSM8351241 62
- GSM8351242 63
- GSM8351243 22
- GSM8351244 38
- GSM8351245 44
- GSM8351246 55
- GSM8351247 64
- GSE246706 Liver-specific matrin-3 knockout alters the hepatic transcriptome of high-fat diet-fed mice [RNA-seq] 16 samples shares liver-specific, high-fat, liver, diet
- GSE310622 Liver-specific suppression of PLA2G6/iPLA2β improves glucose and lipid metabolism via phospholipid remodeling in high-fat diet-fed mice 6 samples shares liver-specific, high-fat, liver, diet
- GSE312316 Maternal Western-Style Diet alters Kupffer Cell proportion leading to Metabolic Dysfunction-Associated Steatotic Liver Disease when challenged with western diet in adulthood 36 samples shares challenged, liver, diet
- GSE312061 Liver-specific delivery of MDM2 antisense oligonucleotides counteracts diet-induced metabolic dysfunction-associated steatotic liver diseases 18 samples shares liver-specific, liver, diet
- GSE317653 Liver-specific loss of the transcriptional coregulator ARGLU1 protects against diet-induced obesity in mice through decreased lipid absorption. 16 samples shares liver-specific, liver, diet
- GSE161147 Transcriptomic changes assoicated with hepatic AHR or ARNT loss in female mice challenged with high-fat diet 12 samples shares challenged, high-fat, diet
- GSE267224 Liver-specific matrin-3 knockout alters the hepatic transcriptome of chow diet-fed mice [RNA-seq] 8 samples shares liver-specific, liver, diet
- GSE264690 Bulk RNA sequencing of livers from high fat diet plus carbon tetrachloride challenged Chrna2 fl/fl and Chrna2 fl/fl;AlbCre mice. 6 samples shares challenged, liver, diet
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.