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Liver-specific matrin-3 knockout alters the hepatic transcriptome of chow diet-fed mice [RNA-seq]

GSE267224 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/10/01 Platform GPL34290
Summary
Matrin-3 is an RNA-binding protein involved in the pathogenesis of human diseases. Here we examined the hepatic transcriptome of chow-diet fed mice. Bulk RNA-seq and bioinformatics analysis identified 646 and 145 differentially expressed genes (Padj < 0.05), respectively in the livers of female and male matrin-3 LKO mice. Enrichr analysis of these DEGs revealed several common Hallmark terms including cholesterol homeostasis, fatty acid metabolism, xenobiotic metabolism, and epithelial mesenchymal transition between female and male mice. Our data demonstrated that liver-specific matrin-3 deficiency re-programs the hepatic transcriptome in the liver of chow diet-fed mice.
Published in
Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor
Cheng X, Baki VB, Moran M et al. · Molecular metabolism 2024 · PMID 38936659 · doi:10.1016/j.molmet.2024.101977
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Also filed as BioProject PRJNA1110273 and SRA study SRP507049. Searching any of these in the dataset finder brings you back here.

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