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Disease-associated microglia signature genes are up-regulated during photoreceptor degeneration

GSE270758 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/07/02 Platform GPL24247
Summary
Retinal degeneration is a collection of devastating conditions with progressive loss of vision which often lead to blindness. Research on retinal microglial cells offers great therapeutic potential in deterring the progression of the condition. This study explored the mechanisms underlying the TREM2-mediated protective function of activated microglial cells during retinal degeneration. A significant upregulation of disease-associated microglia signature genes was observed during photoreceptor degeneration.
Published in
TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARγ and CD36
Zhou W, He J, Shen G et al. · Cell death & disease 2024 · PMID 39187498 · doi:10.1038/s41419-024-07002-z
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Also filed as BioProject PRJNA1128127 and SRA study SRP516072. Searching any of these in the dataset finder brings you back here.

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