MYC couples SWI/SNF and metabolic reprogramming to sustain minimal residual disease in mTORC1-activated cancer cells [CUT&RUN, ATAC-seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 32 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 32 samples: 14 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270774_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1128150 and SRA study SRP516060. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 14 replicated groups read from 32 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8351698 H101_MYC_Rep1 H101_MYC
- GSM8351699 H101_MYC_Rep2 H101_MYC
- GSM8351700 H101RP_MYC_Rep1 H101RP_MYC
- GSM8351701 H101RP_MYC_Rep2 H101RP_MYC
- GSM8351702 H101_H3K27ac_Rep1 H101_H3K27ac
- GSM8351703 H101_H3K27ac_Rep2 H101_H3K27ac
- GSM8351704 H101RP_H3K27ac_Rep1 H101RP_H3K27ac
- GSM8351705 H101RP_H3K27ac_Rep2 H101RP_H3K27ac
- GSM8351706 H101_ATAC_Rep1 H101_ATAC
- GSM8351707 H101_ATAC_Rep2 H101_ATAC
- GSM8351708 H101RP_ATAC_Rep1 H101RP_ATAC
- GSM8351709 H101RP_ATAC_Rep2 H101RP_ATAC
- GSM8351710 m705_MYC_Rep1 m705_MYC
- GSM8351711 m705_MYC_Rep2 m705_MYC
- GSM8351712 m705RP_MYC_Rep1 m705RP_MYC
- GSM8351713 m705RP_MYC_Rep2 m705RP_MYC
- GSM8351714 m705_H3K4me1_Rep1
- GSM8351715 m705RP_H3K4me1_Rep1
- GSM8351716 m705_H3K4me3_Rep1
- GSM8351717 m705RP_H3K4me3_Rep1
- GSM8351718 m705_H3K9Lac_Rep1 m705_H3K9Lac
- GSM8351719 m705_H3K9Lac_Rep2 m705_H3K9Lac
- GSM8351720 m705RP_H3K9Lac_Rep1 m705RP_H3K9Lac
- GSM8351721 m705RP_H3K9Lac_Rep2 m705RP_H3K9Lac
- GSM8351722 m705_H3K27ac_Rep1 m705_H3K27ac
- GSM8351723 m705_H3K27ac_Rep2 m705_H3K27ac
- GSM8351724 m705RP_H3K27ac_Rep1 m705RP_H3K27ac
- GSM8351725 m705RP_H3K27ac_Rep2 m705RP_H3K27ac
- GSM8351726 m705_ATAC_Rep1 m705_ATAC
- GSM8351727 m705_ATAC_Rep2 m705_ATAC
- GSM8351728 m705RP_ATAC_Rep1 m705RP_ATAC
- GSM8351729 m705RP_ATAC_Rep2 m705RP_ATAC
- GSE270779 MYC couples SWI/SNF and metabolic reprogramming to sustain minimal residual disease in mTORC1-activated cancer cells 64 samples shares myc, swi, snf, mtorc1-activated, reprogramming, residual
- GSE270777 MYC couples SWI/SNF and metabolic reprogramming to sustain minimal residual disease in mTORC1-activated cancer cells [RNA-seq] 18 samples shares myc, swi, snf, mtorc1-activated, reprogramming, residual
- GSE298543 Persistent dopamine-dependent remodeling of the neural transcriptome in response to pregnancy and postpartum [CUT&RUN] 88 samples shares cut, run
- GSE253750 Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [Cut&Run] 87 samples shares cut, run
- GSE299380 KAT6A Chimeras Forms a Self-Reinforcing Epigenetic Module with NURF and MLL/COMPASS in AML [CUT&Run] 33 samples shares cut, run
- GSE284653 Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis [PROX1 CUT&RUN Liver/MEF/Hep3B] 22 samples shares cut, run
- GSE289448 DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights [CUT&RUN] 21 samples shares cut, run
- GSE278481 EZH2 INHIBITION ENHANCES T CELL IMMUNOTHERAPIES BY INDUCING LYMPHOMA IMMUNOGENICITY AND IMPROVING T CELL FUNCTION (CUT&RUN) 16 samples shares cut, run
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.