← BioTransfer GEO Dataset Finder
GEO series

Intratumoral NKT cell accumulation promotes antitumor immunity in pancreatic cancer

GSE270858 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/07 Platform GPL19057
Summary
Here, using the mouse KRT19-deficient (sgKRT19-edited) PDA model, we find that intratumoral accumulation of natural killer T (NKT) cells are required to establish an immunologically active TME. Mechanistically, intratumoral NKT cells facilitate type I interferon (IFN) production to initiate an anti-tumor adaptive immune response, and orchestrate the intratumoral infiltration of T cells, dendritic cells, natural killer cells and myeloid-derived suppressor cells. At the molecular level, NKT cells promote the production of type I IFN through the interaction of their CD40L with CD40 on myeloid cells. To evaluate the theraputical potential of these observations, we find that administration of folinic acid to mice bearing PDA increases NKT cells in the TME and improves their response to anti-PD-1 antibody treatment. In conclusion, NKT cells have an essential role in the immune response to mouse PDA and are potential targets for immunotherapy.
Published in
Intratumoral NKT cell accumulation promotes antitumor immunity in pancreatic cancer
Li J, Moresco P, Fearon DT · Proceedings of the National Academy of Sciences of the United States of America 2024 · PMID 38980903 · doi:10.1073/pnas.2403917121
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE270858_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1128647 and SRA study SRP516355. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.