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Molecular and Cellular Mechanisms of Heart Failure With Preserved Ejection Fraction

GSE270896 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/07/12 Platform GPL24247
Summary
To understand the cellular mechanisms of heart failure with preserved ejection fraction (HFpEF), We investigated the functional outcome and the underlying mechanisms from concurrent mechanic and metabolic stresses in the heart by applying transverse aortic constriction (TAC) in lean C57Bl/6J (HFrEF phenotype) or obese/diabetic B6.Cg-Lepob/J (ob/ob) mice (HFpEF phenotype) followed by single-nuclei RNA-seq (snRNA-seq) and targeted manipulation of a top ranked signaling pathway (glucagon receptor signaling) differentially affected in the two experimental cohorts.
Published in
Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction
Gao C, Xiong Z, Liu Y et al. · Circulation research 2024 · PMID 39011638 · doi:10.1161/CIRCRESAHA.124.324706
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Also filed as BioProject PRJNA836041 and SRA study SRP374095. Searching any of these in the dataset finder brings you back here.

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