Linker histone H1-0 is a specific mediator of the ETV6::RUNX1 transcriptional landscape in preleukemia and B cell acute lymphoblastic leukemia [RNA-seq]
Single-cell RNA-seq · human · 26 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Topic
- Acute lymphoblastic leukemiaThis series is part of our curated briefing on it.
- Samples
- 26 samples: 7 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- H1-0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape in preleukemia and B cell acute lymphoblastic leukemiaHemaSphere · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270944_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1129088 and SRA study SRP516564. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 26 samples.
How we read this: 7 replicated groups read from 26 sample titles; they account for 26 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8365484 HW8, WT, replicate 1 HW8, WT,
- GSM8365485 HW8, WT, replicate 2 HW8, WT,
- GSM8365486 HW8, WT, replicate 3 HW8, WT,
- GSM8365487 HW8, ETV6::RUNX1, clone 1, replicate 1 RUNX1, clone 1,
- GSM8365488 HW8, ETV6::RUNX1, clone 1, replicate 2 RUNX1, clone 1,
- GSM8365489 HW8, ETV6::RUNX1, clone 1, replicate 3 RUNX1, clone 1,
- GSM8365490 HW8, ETV6::RUNX1, clone 2, replicate 1 RUNX1, clone 2,
- GSM8365491 HW8, ETV6::RUNX1, clone 2, replicate 2 RUNX1, clone 2,
- GSM8365492 HW8, ETV6::RUNX1, clone 2, replicate 3 RUNX1, clone 2,
- GSM8365493 ChiPSC12, WT, replicate 1 ChiPSC12, WT,
- GSM8365494 ChiPSC12, WT, replicate 2 ChiPSC12, WT,
- GSM8365495 ChiPSC12, WT, replicate 3 ChiPSC12, WT,
- GSM8365496 ChiPSC12, ETV6::RUNX1, clone 1, replicate 1 RUNX1, clone 1,
- GSM8365497 ChiPSC12, ETV6::RUNX1, clone 1, replicate 2 RUNX1, clone 1,
- GSM8365498 ChiPSC12, ETV6::RUNX1, clone 1, replicate 3 RUNX1, clone 1,
- GSM8365499 siCtrl, replicate 1 siCtrl,
- GSM8365500 siCtrl, replicate 2 siCtrl,
- GSM8365501 siCtrl, replicate 3 siCtrl,
- GSM8365502 siCtrl, replicate 4 siCtrl,
- GSM8365503 siH1-0_1, replicate 2 siH1-0_1,
- GSM8365504 siH1-0_1, replicate 3 siH1-0_1,
- GSM8365505 siH1-0_1, replicate 4 siH1-0_1,
- GSM8365506 siH1-0_2, replicate 1 siH1-0_2,
- GSM8365507 siH1-0_2, replicate 2 siH1-0_2,
- GSM8365508 siH1-0_2, replicate 3 siH1-0_2,
- GSM8365509 siH1-0_2, replicate 4 siH1-0_2,
- GSE115656 Alternative splicing analysis of pediatric B-cell acute lymphoblastic leukemia compared to normal bone marrow derived pro-B cells 38 samples same disease briefing · shares lymphoblastic, leukemia
- GSE12995 Expression data for diagnosis acute lymphoblastic leukemia samples 175 samples same disease briefing · shares lymphoblastic, leukemia
- GSE160298 The chromatin accessibility landscape of T-Cell Acute Lymphoblastic Leukemia 80 samples same disease briefing · shares lymphoblastic, leukemia
- GSE13425 Expression data from ALL patients included in the set used to construct a classification signature (COALL cohort) 190 samples same disease briefing
- GSE154675 PHF6 Interacts with LMO2 During Normal Haematopoiesis and in Leukaemia and Regulates the Level of Gene Expression and Genome Integrity 41 samples same disease briefing
- GSE193713 Genome-wide maps of chromatin state for histone modifications and chromatin remodeling factors in WT and PHF6-KO conditions in Jurkat T-ALL cells. 20 samples same disease briefing
- GSE18198 Expression profile of human T-ALL cell lines treated with DMSO or SAHM1 12 samples same disease briefing
- GSE283119 Linker histone H1-0 is a specific mediator of the ETV6::RUNX1 transcriptional landscape in preleukemia and B cell acute lymphoblastic leukemia 24 samples shares runx1, h1-0, etv6, lymphoblastic, preleukemia, specific, mediator, leukemia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.