GEO series
RARb and Huntington Disease
GSE270980
Mus musculus
Expression profiling by high throughput sequencing
11 samples
2025/04/29
GPL21103
Summary
Our working hypothesis is that two genetic factors A (compromized Rarβ expression in Rarβ+/- mice) and B (mutant form of huntingtin; R6/1 Tg/0) can synergise in generating physiopathology of Huntington disease. To address this point we performed comparative transcritomics in the nucleus accumbens (NAc) for 4 experimental groups : 1) R6/1 Tg/0 ; Rarβ+/-, (n=3); 2) R6/1 Tg/0 ; Rarβ+/+, (n=3); 3) R6/1 0/0 ; Rarβ+/-, (n=3); 4) R6/1 0/0 ; Rarβ+/+ (n=2).
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