Zika virus exploits autophagy for replication in human trabecular meshwork and autophagic inhibition at autolysomal maturation ameliorates Zika-induced ocular complications.
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × Mock vs 3 × Hydroxychloroquine + ZIKV vs 3 × Rapamycin + ZIKV vs 3 × ZIKV onlyGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Zika virus impairs autophagic flux in trabecular meshwork, and inhibition of autophagy restricts ocular viral transmission and associated pathologyMicrobiology spectrum · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE270987_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1129154 and SRA study SRP516625. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8366615 Mock 1 Mock
- GSM8366616 Mock 2 Mock
- GSM8366617 Mock 3 Mock
- GSM8366618 Hydroxychloroquine + ZIKV 1 Hydroxychloroquine + ZI…
- GSM8366619 Hydroxychloroquine + ZIKV 2 Hydroxychloroquine + ZI…
- GSM8366620 Hydroxychloroquine + ZIKV 3 Hydroxychloroquine + ZI…
- GSM8366621 Rapamycin + ZIKV 1 Rapamycin + ZIKV
- GSM8366622 Rapamycin + ZIKV 2 Rapamycin + ZIKV
- GSM8366623 Rapamycin + ZIKV 3 Rapamycin + ZIKV
- GSM8366624 ZIKV only 1 ZIKV only
- GSM8366625 ZIKV only 2 ZIKV only
- GSM8366626 ZIKV only 3 ZIKV only
- GSE268776 Multi-omics approaches reveal that Diffuse Midline Gliomas are susceptible to replication stress therapy and cholesterol biosynthesis inhibition [RNA-seq] 64 samples shares replication, inhibition
- GSE292828 Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications [scRNA-seq] 39 samples shares complications, inhibition
- GSE270204 Therapeutic efficacy of CDK7 inhibition in pancreatic cancer through proliferation arrest and inducing replication stress [8898T] 15 samples shares replication, inhibition
- GSE325471 The CDK4/6 inhibitor dalpiciclib augments the antitumor efficacy of enzalutamide in preclinical models of castration-resistant prostate cancer through inhibition of MCM4-mediated DNA replication 12 samples shares replication, inhibition
- GSE292829 Inhibition of NFAT after human uterus transplant promotes loss of tissue-resident NK cells and attendant pregnancy complications [CITE-seq] 58 samples shares complications, inhibition
- GSE281513 Inhibition of DEK contributes to the tolerance of replication stress and restores HSC function in Fanconi anemia [12-ATAC] 10 samples shares replication, inhibition
- GSE261018 Urine Cell-Free RNA versus Plasma Cell-Free RNA for Monitoring of Immune and Urinary Tract Complications 272 samples shares complications
- GSE325454 Mitochondrial OXPHOS restricts SARS-CoV-2 replication 148 samples shares replication
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.