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Acetate is a driver of quiescence in ovarian cancer

GSE271035 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/16 Platform GPL20301
Summary
While prior work in muscle cells indicates that metabolic reprogramming is associated with quiescence, whether metabolic changes occur in cancer to drive quiescence is unclear. Using a multi-omics approach, we found that the metabolic enzyme ACSS2 is both highly upregulated in quiescent cells and required for their survival. ACSS2 converts acetate into acetyl-CoA, and we confirmed increased acetate-derived acetyl-CoA in quiescent cells, demonstrating increased ACSS2 activity. Interestingly, supplementing cells with acetate alone was sufficient to induce a reversible quiescent cell cycle exit.
Published in
Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production
Sharrow AC, Megill E, Chen AJ et al. · Molecular metabolism 2024 · PMID 39304063 · doi:10.1016/j.molmet.2024.102031
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Also filed as BioProject PRJNA1129463 and SRA study SRP516811. Searching any of these in the dataset finder brings you back here.

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