← BioTransfer GEO Dataset Finder
GEO series

Serum starvation induces quiescence in ovarian cancer

GSE271357 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/16 Platform GPL20301
Summary
While prior work in muscle cells indicates that metabolic reprogramming is associated with quiescence, whether metabolic changes occur in cancer to drive quiescence is unclear. We found that the metabolic enzyme ACSS2 is highly upregulated in quiescent ovarian cancer cells and overexpresssion of ACSS2 induces ovarian cancer quiescence.
Published in
Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production
Sharrow AC, Megill E, Chen AJ et al. · Molecular metabolism 2024 · PMID 39304063 · doi:10.1016/j.molmet.2024.102031
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE271357_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1130989 and SRA study SRP517618. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.