CGRP-Related Neuropeptide Adrenomedullin 2 Promotes Tissue-Protective ILC2 Responses and Limits Intestinal Inflammation
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 11 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammationNature immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271362_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1130984 and SRA study SRP517633. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 11 sample titles: 11 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8375437 A1_Veh
- GSM8375438 A2_Veh
- GSM8375439 A3_Veh
- GSM8375440 B1_ADM2
- GSM8375441 B2_ADM2
- GSM8375442 B3_ADM2
- GSM8375443 C1_IL25
- GSM8375444 C2_IL25
- GSM8375445 C3_IL25
- GSM8375446 D2_IL25_ADM2
- GSM8375447 D3_IL25_ADM2
- GSE101623 The neuropeptide Neuromedin U stimulates innate lymphoid cells and promotes type 2 inflammation [ILC2 and ILC3] 6 samples shares ilc2, neuropeptide, promotes
- GSE301976 IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 2] 12 samples shares ilc2, intestinal
- GSE180075 Type I interferon limits ILC2 effector functions through suppression of the CCR8-CCL1/CCL8 axis 10 samples shares ilc2, limits
- GSE301975 IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1] 8 samples shares ilc2, intestinal
- GSE336792 Stem cell factor 248 shapes ILC2 transcriptional programs and promotes mucosal inflammation in allergic asthma 4 samples shares ilc2, promotes
- GSE301999 IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-seq] 4 samples shares ilc2, intestinal
- GSE287676 mTORC1 promotes adipose tissue ILC2 homeostasis through upregulation of PPARγ 4 samples shares ilc2, promotes
- GSE290467 Functional Targeting of ILC2s and ILC3s reveals selective roles in intestinal fibrosis and homeostasis. 3 samples shares ilc2, intestinal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.