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Effect of complete abroagation of hyaluronan synthesis on osteogenic differentiation of mesenchymal stem cells (MSc) in vitro

GSE271507 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/07/05 Platform GPL24247
Summary
Mesenchymal stem cells (MSc) show diminished osteogenic differentiation upon complete knockout of all known Hyaluronan (HA) synthases (Has). We demonstrated that Has-knockout completely abrogated the release of HA into the culture medium by MSc and that these MSc showed an impaired osteogenic differentiation detected by Alizarin red staining at days 7 and 12 of differentiation compared to wildtype MSc. To gain insight intor the transcriptomic changes due to Has knockout we compared differentiating MSc at day 7 of differentiation.
Published in
Bone quality relies on hyaluronan synthesis - Insights from mice with complete knockout of hyaluronan synthase expression
Saalbach A, Stein M, Lee S et al. · Matrix biology plus 2024 · PMID 39736893 · doi:10.1016/j.mbplus.2024.100163
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Also filed as BioProject PRJNA1132131 and SRA study SRP518084. Searching any of these in the dataset finder brings you back here.

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