Microglia innate immune memory is retained after enforced repopulation [RNA-seq]
RNA-seq (gene expression) · mouse · 29 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 29 samples: 6 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Microglia endotoxin tolerance is retained after enforced repopulationBrain, behavior, and immunity · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271535_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1132173 and SRA study SRP518122. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 29 samples.
How we read this: 6 replicated groups read from 29 sample titles; they account for 29 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8378950 PBP_1 PBP
- GSM8378951 PBP_2 PBP
- GSM8378952 PBP_3 PBP
- GSM8378953 PBP_4 PBP
- GSM8378954 PBP_5 PBP
- GSM8378955 PP_1 PP
- GSM8378956 PP_2 PP
- GSM8378957 PP_3 PP
- GSM8378958 PP_4 PP
- GSM8378959 PP_5 PP
- GSM8378960 PBL_1 PBL
- GSM8378961 PBL_2 PBL
- GSM8378962 PBL_3 PBL
- GSM8378963 PBL_4 PBL
- GSM8378964 PBL_5 PBL
- GSM8378965 PL_1 PL
- GSM8378966 PL_2 PL
- GSM8378967 PL_3 PL
- GSM8378968 PL_4 PL
- GSM8378969 LBL_1 LBL
- GSM8378970 LBL_2 LBL
- GSM8378971 LBL_3 LBL
- GSM8378972 LBL_4 LBL
- GSM8378973 LBL_5 LBL
- GSM8378974 LL_1 LL
- GSM8378975 LL_2 LL
- GSM8378976 LL_3 LL
- GSM8378977 LL_4 LL
- GSM8378978 LL_5 LL
- GSE270935 Microglia innate immune memory is retained after enforced repopulation [ATAC-seq] 13 samples shares repopulation, microglia, retained, enforced, innate, memory
- GSE341988 Sequential pathogen exposure normalizes the brain neuroimmune microenvironment and reveals a tissue-resident memory CD8 T cell-microglia axis shaping adult neurogenesis 8 samples shares microglia, memory
- GSE264105 Plate-based scRNA-seq of plasma-positive microglia and plasma-negative microglia in young mice 1111 samples shares microglia, rna-seq
- GSE98969 Single cell RNA-seq identifies a unique microglia type associated with Alzheimer’s disease [RNA] 97 samples shares microglia, rna-seq
- GSE302857 Multi-tier signaling and epigenomic reprogramming drive microglial inflammatory states and functions associated with demyelination [RNA-seq] 81 samples shares microglia, rna-seq
- GSE278199 Microglia regulate cortical remyelination via ΤNFR1-dependent phenotypic polarization [scRNA-Seq] 45 samples shares microglia, rna-seq
- GSE226938 Early amyloid-induced changes in microglia gene expression in APP/PS1 mice [scRNA-seq] 36 samples shares microglia, rna-seq
- GSE285895 Simulating Neonatal Microglial Pan-Programmed Cell Death to Unlock Regenerative Potential in Adult Mice Spinal Cord Injury [RNA-seq] 21 samples shares microglia, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.