← BioTransfer GEO Dataset Finder
GEO series

The chromatin remodeler Brg1 is essential for cochlear sensory epithelium differentiation and patterning

GSE271610 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2025/12/01 Platform GPL24247
Summary
The development of the organ of Corti requires the coordination of cell differentiation and patterning, which results in the formation of unique functional units critical for sound detection. Here, we investigated the role of the epigenetic factor Brg1 during the differentiation and development of the auditory sensory epithelium, a crucial period for the formation of the organ of Corti. Our findings indicate that deletion of Brg1 leads to premature hair cell (HC) differentiation by inactivating Sonic hedgehog (Shh) signaling. Despite the formation of HCs, subsequent differentiation of inner hair cells (IHCs) and outer hair cells (OHCs) was impaired. Additionally, we observed that the mosaic-like arrangement of HCs and supporting cells (SCs) was disrupted resulting in abnormal sensory epithelium patterning. Furthermore, we found the planar cell polarity of the Brg1-deficient cochlea was abnormal. Our study demonstrates the pivotal role of Brg1 in the differentiation and patterning of the auditory sensory epithelium.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE271610_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1132284 and SRA study SRP518224. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 7 more — browse all 7 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.