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Cellular Communication Network Factor 3 contributes to the pathological process of rheumatoid arthritis via promoting cell senescence in synovial cells

GSE271643 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/26 Platform GPL24676
Summary
Cellular Communication Network Factor 3 (CCN3) is a secreted protein. It belongs to the CCN family of regulatory proteins, which play essential roles in various cellular processes. In this study, we investigated the functional characteristics of CCN3 in rheumatoid arthritis. We found CCN3 is involved in cellular senescence and inflammation of fibroblast like synoviocyte (FLS) in vitro. To understand this mechanism, CCN3 is were added to FLS and their responses were examined by bulk-RNA analysis.
Published in
Cellular communication network factor 3 contributes to the pathological process of rheumatoid arthritis through promoting cell senescence and osteoclastogenesis in the joint
Tokuhiro T, Matsumae G, Endo T et al. · Journal of autoimmunity 2024 · PMID 39549484 · doi:10.1016/j.jaut.2024.103334
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Also filed as BioProject PRJNA1132678 and SRA study SRP518343. Searching any of these in the dataset finder brings you back here.

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