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Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming

GSE271802 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/04 Platform GPL28038
Summary
Colorectal cancer (CRC) is a common malignant neoplasm influenced by both genetic and environmental factors, and its incidence correlates with the composition of the gut microbiota. Relevant studies have demonstrated that gut microbiota dysbiosis is associated with CRC progression. However, the relationship between CRC tumor proliferation and dysregulation of tryptophan metabolism remains unclear. Our investigation addresses the role and mechanisms of amino acid metabolites in tumor progression based on the dysregulation of tryptophan metabolism in clinical CRC patients. Using metagenomic sequencing and targeted tryptophan metabolomics, our research delineates the aberrant levels of indole-3-lactic acid (ILA) in CRC patients. ILA inhibits glycolysis via the STAT3-HK2 axis and exerts a suppressive effect on CRC independent of the aryl hydrocarbon receptor (AHR). By elucidating the inhibitory role of ILA in CRC and uncovering its underlying mechanisms, our study provides a prospective therapeutic avenue for CRC treatment.
Published in
Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming
Zhou S, Wang K, Huang J et al. · Gut microbes 2025 · PMID 40409349 · doi:10.1080/19490976.2025.2508949
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Also filed as BioProject PRJNA1133650 and SRA study SRP518715. Searching any of these in the dataset finder brings you back here.

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