GEO series
Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury
GSE271903
Mus musculus
Expression profiling by high throughput sequencing
61 samples
2024/07/17
GPL28457
Summary
Osteoarthritis (OA) is a disease with sex-dependent prevalence and severity in both human and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (ACLR) mouse model of post-traumatic OA (PTOA).
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Paper (PMID 37716404) ↗
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