LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 153 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 153 samples: 50 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLCNature communications · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272003_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1134608 and SRA study SRP519276. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 153 samples.
How we read this: 50 replicated groups read from 153 sample titles; they account for 153 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8390756 INPUT_DMSO_rep1 INPUT_DMSO
- GSM8390757 INPUT_DMSO_rep2 INPUT_DMSO
- GSM8390758 INPUT_DMSO_rep3 INPUT_DMSO
- GSM8390759 INPUT_DMSO_rep4 INPUT_DMSO
- GSM8390760 INPUT_TAS1440_rep1 INPUT_TAS1440
- GSM8390761 INPUT_TAS1440_rep2 INPUT_TAS1440
- GSM8390762 INPUT_TAS1440_rep3 INPUT_TAS1440
- GSM8390763 INPUT_TAS1440_rep4 INPUT_TAS1440
- GSM8390764 INPUT_ORY1001_rep1 INPUT_ORY1001
- GSM8390765 INPUT_ORY1001_rep2 INPUT_ORY1001
- GSM8390766 INPUT_ORY1001_rep3 INPUT_ORY1001
- GSM8390767 INPUT_ORY1001_rep4 INPUT_ORY1001
- GSM8390768 INPUT_GSK2879552_rep1 INPUT_GSK2879552
- GSM8390769 INPUT_GSK2879552_rep2 INPUT_GSK2879552
- GSM8390770 INPUT_GSK2879552_rep3 INPUT_GSK2879552
- GSM8390771 INPUT_GSK2879552_rep4 INPUT_GSK2879552
- GSM8390772 Anti-H3K4me1_DMSO_rep1 Anti-H3K4me1_DMSO
- GSM8390773 Anti-H3K4me1_DMSO_rep2 Anti-H3K4me1_DMSO
- GSM8390774 Anti-H3K4me1_DMSO_rep3 Anti-H3K4me1_DMSO
- GSM8390775 Anti-H3K4me1_TAS1440_rep1 Anti-H3K4me1_TAS1440
- GSM8390776 Anti-H3K4me1_TAS1440_rep2 Anti-H3K4me1_TAS1440
- GSM8390777 Anti-H3K4me1_TAS1440_rep3 Anti-H3K4me1_TAS1440
- GSM8390778 Anti-H3K4me1_ORY1001_rep1 Anti-H3K4me1_ORY1001
- GSM8390779 Anti-H3K4me1_ORY1001_rep2 Anti-H3K4me1_ORY1001
- GSM8390780 Anti-H3K4me1_ORY1001_rep3 Anti-H3K4me1_ORY1001
- GSM8390781 Anti-H3K4me1_GSK2879552_rep1 Anti-H3K4me1_GSK2879552
- GSM8390782 Anti-H3K4me1_GSK2879552_rep2 Anti-H3K4me1_GSK2879552
- GSM8390783 Anti-H3K4me1_GSK2879552_rep3 Anti-H3K4me1_GSK2879552
- GSM8390784 Anti-H3K4me2_DMSO_rep1 Anti-H3K4me2_DMSO
- GSM8390785 Anti-H3K4me2_DMSO_rep2 Anti-H3K4me2_DMSO
- GSM8390786 Anti-H3K4me2_DMSO_rep3 Anti-H3K4me2_DMSO
- GSM8390787 Anti-H3K4me2_TAS1440_rep1 Anti-H3K4me2_TAS1440
- GSM8390788 Anti-H3K4me2_TAS1440_rep2 Anti-H3K4me2_TAS1440
- GSM8390789 Anti-H3K4me2_TAS1440_rep3 Anti-H3K4me2_TAS1440
- GSM8390790 Anti-H3K4me2_ORY1001_rep1 Anti-H3K4me2_ORY1001
- GSM8390791 Anti-H3K4me2_ORY1001_rep2 Anti-H3K4me2_ORY1001
- GSM8390792 Anti-H3K4me2_ORY1001_rep3 Anti-H3K4me2_ORY1001
- GSM8390793 Anti-H3K4me2_GSK2879552_rep1 Anti-H3K4me2_GSK2879552
- GSM8390794 Anti-H3K4me2_GSK2879552_rep2 Anti-H3K4me2_GSK2879552
- GSM8390795 Anti-H3K4me2_GSK2879552_rep3 Anti-H3K4me2_GSK2879552
+ 113 more — browse all 153 samples with per-sample file links →
- GSE272002 LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC 324 samples shares insm1-lsd1, tas1440, lsd1, sclc, tumor-suppressive, neuroendocrine, reprogramming, activating
- GSE66297 A DNA Hypomethylation Signature Predicts Novel Anti-Tumor Activity of LSD1 Inhibitors in SCLC (ChIP-Seq) 6 samples shares lsd1, sclc
- GSE66298 A DNA Hypomethylation Signature Predicts Novel Anti-Tumor Activity of LSD1 Inhibitors in SCLC 136 samples shares lsd1, sclc
- GSE66295 A DNA Hypomethylation Signature Predicts Novel Anti-Tumor Activity of LSD1 Inhibitors in SCLC (BeadChip) 42 samples shares lsd1, sclc
- GSE117570 Reprogramming of Tumor-infiltrating Immune Cells in Early Stage of NSCLC 8 samples shares sclc, reprogramming
- GSE330687 PD-L1 drives metabolic reprogramming and mitochondrial remodeling in NSCLC cells 6 samples shares sclc, reprogramming
- GSE231736 The application of ChIP-seq to study LSD1 and hematopoietic TF binding on enhancers upon LSD1 inhibition. 42 samples shares lsd1
- GSE300505 The histone-methyltransferase DOT1L cooperates with LSD1 to control cell division in blast-phase MPN [ChIP-seq] 37 samples shares lsd1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.