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Investigating the Impact of adriamycin resistance on Gene Expression in MDA-MB-231 Breast Cancer Cells

GSE272101 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/30 Platform GPL34281
Summary
Cellular mechanisms driving aggressive phenotypes in drug-resistant cancer cells remain to be fully elucidated. This study investigated the differences between MDA-MB-231 adriamycin-resistant cells and their parental counterparts, focusing on cell death, motility, proliferation, and key signaling pathways. Compared to parental cells, the resistant cells exhibited significantly increased cell death resistance, enhanced motility and proliferation, and upregulated NF-κB and STAT3 signaling. These findings suggest that heightened survival mechanisms, increased migratory and proliferative capacity, and dysregulated signaling pathways contribute to the aggressive behavior of adriamycin-resistant MDA-MB-231 cells.
Published in
MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer
Lee CH, Park SY, Lee JS et al. · Breast cancer research : BCR 2025 · PMID 40696387 · doi:10.1186/s13058-025-02072-z
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Also filed as BioProject PRJNA1135121 and SRA study SRP519543. Searching any of these in the dataset finder brings you back here.

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