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Investigating the Impact of Genetic MSN Depletion on Gene Expression in MDA-MB-231 Breast Cancer Cells

GSE272103 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/30 Platform GPL34281
Summary
Cellular differentiation is a tightly regulated process, relying on the precise interplay between lineage-specific transcription factors and epigenetic modifications to both initiate and sustain distinct cell fates. Here, we report Moesin as a key regulator of tumor growth and metastasis in the MDA-MB-231 breast cancer cell line. MSN, a linker between the actin cytoskeleton and the plasma membrane, regulates cell morphology and motility. Our results demonstrate that MSN depletion impairs microtubule cytoskeleton organization and microtubule polymerization. Furthermore, we observed elevated MSN levels in Triple-Negative Breast Cancer cells, which exhibit aggressive growth characteristics. Taken together, our data reveal a crucial role for MSN in mediating tumor growth and metastasis, thereby contributing to the aggressiveness of breast cancer.
Published in
MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer
Lee CH, Park SY, Lee JS et al. · Breast cancer research : BCR 2025 · PMID 40696387 · doi:10.1186/s13058-025-02072-z
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Also filed as BioProject PRJNA1135119 and SRA study SRP519545. Searching any of these in the dataset finder brings you back here.

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