GEO series
Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma [scRNA-seq]
GSE272237
Mus musculus
Expression profiling by high throughput sequencing
11 samples
2025/10/03
GPL24247
Summary
To functionally assess the role of pericytes in glioma development and progression, we study the effects of pericyte depletion in orthotopic and transgenic mouse models of high-grade glioma using single-cell and spatial transcriptomics. We present evidence that pericytes mitigate glioma development by orchestrating a tumor-suppressive microenvironment, challenging the concept of pericytes as merely pro-oncogenic cells, and underscoring the importance of pericyte preservation in future GBM therapies.
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Paper (PMID 41339360) ↗
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