Upregulation of adenosine A2A receptor by astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficits
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Upregulation of adenosine A(2A) receptor in astrocytes is sufficient to trigger hippocampal multicellular dysfunctions and memory deficitsMolecular psychiatry · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272248_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1135951 and SRA study SRP519928. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8397058 303_GFP
- GSM8397059 306_GFP
- GSM8397060 307_GFP
- GSM8397061 309_A2A
- GSM8397062 310_A2A
- GSM8397063 313_A2A
- GSM8680274 CD11b_2343_A2AR
- GSM8680275 CD11b_2344_A2AR
- GSM8680276 CD11b_2347_A2AR
- GSM8680277 CD11b_2328_Control
- GSM8680278 CD11b_2329_Control
- GSM8680279 CD11b_2331_Control
- GSE236563 Remdesivir has previously unknown anti-viral immunomodulatory properties through the Adenosine A2A Receptor pathway 16 samples shares a2a, adenosine
- GSE283112 Large-scale reorganization of DNA methylation and upregulation of extracellular matrix genes in cocaine reward-related hippocampal learning [RNA-seq] 10 samples shares upregulation, hippocampal
- GSE242450 Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2 6 samples shares upregulation, astrocytes
- GSE304258 Development of a novel peripherally acting alpha2A- adrenergic receptor antagonist for anti-diabetic 2 samples shares a2a
- GSE310452 Sustained A2AR expression and loss paradoxically promote CD8+ T cell exhaustion 12 samples shares a2a
- GSE313209 Hv1 upregulation worsens spinal, spleen, and lung molecular pathology and impairs locomotion after spinal cord injury in aged male mice 123 samples shares upregulation
- GSE254996 ACSS2 upregulation enhances neuronal resilience to aging and neurodegeneration [RNA-seq] 98 samples shares upregulation
- GSE245605 WWOX promotes osteosarcoma development via upregulation of Myc [RNA-Seq] 37 samples shares upregulation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.