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Sex differences in DNMT3A-mutant clonal hematopoiesis and the effects of estrogen [scATAC-Seq]

GSE272265 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/04/04 Platform GPL24247
Summary
Blood cancers are generally more common in males, and the prevalence of most mutations that drive clonal hematopoiesis and myeloid malignancies is higher in males. In contrast, hematopoietic DNMT3A mutations are more common in females. We sought to investigate if sex hormones might contribute to the female predominance of DNMT3A mutations. We used single-cell RNA- and ATAC-sequencing in murine models to examine genotype-specific sex differences and sex hormone effects on hematopoietic stem and progenitor cells.
Published in
Sex differences in DNMT3A-mutant clonal hematopoiesis and the effects of estrogen
Stomper J, Niroula A, Belizaire R et al. · Cell reports 2025 · PMID 40178977 · doi:10.1016/j.celrep.2025.115494
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Also filed as BioProject PRJNA1135978 and SRA study SRP519961. Searching any of these in the dataset finder brings you back here.

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