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Cyclic stretch and interstial sitffness effects on A549 cells

GSE272292 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/09/30 Platform GPL18573
Summary
The mechanical properties and forces in the extracellular environment surrounding alveolar epithelial cells modulate their behavior. Particularly, breathing applies 3-dimensional cyclic stretch to the cells, while diseases such as cancer or fibrosis induce stiffening of the interstitium. To model this behavior, a biomimetic device was developed that effectively imitates the active forces in the alveolus, while allowing one to control the interstitium matrix stiffnesses to recreate different mechanical environments to replicate lung diseases. Alveolar epithelial A549 cancer cells were cultured on the platforms and their transcriptome was profiled using RNA sequencing.
Published in
Targeting nanoparticles to lung cancer-derived A549 cells based on changes on interstitial stiffness in biomimetic models
Kohon AI, Man K, Hessami A et al. · iScience 2024 · PMID 39435151 · doi:10.1016/j.isci.2024.111015
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Also filed as BioProject PRJNA1136037 and SRA study SRP520009. Searching any of these in the dataset finder brings you back here.

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