GEO series

The Genetic Basis of Hypodiploid Acute Lymphoblastic Leukemia

GSE27237 Homo sapiens Expression profiling by array 118 samples Submitted 2013/01/15 Platform GPL13158

Summary

The genetic basis of hypodiploid acute lymphoblastic leukemia (ALL), characterized by aneuploidy and poor outcome, is unknown. Here, using complementary genome-wide profiling approaches, we show that hypodiploid ALL comprises two major subtypes that differ in the severity of aneuploidy, transcriptional profile and submicroscopic genetic alterations. Near haploid cases with 24-31 chromosomes frequently harbor alterations targeting receptor tyrosine kinase- and Ras signaling (71%) and IKZF3 (AIOLOS; 13%). In contrast, low hypodiploid ALL cases with 32-39 chromosomes are characterized by TP53 alterations (88%), almost half of which are present in non-tumor cells, and have alterations of IKZF2 (HELIOS; 53%) and RB1 (41%). Both near haploid and low hypodiploid tumors exhibit activation of Ras and PI3K signaling pathways, and are sensitive to PI3K inhibition, indicating that these drugs should be explored as a new therapeutic strategy for this frequently lethal form of leukemia.

This dataset

Open GSE27237 in finder → Find more human microarray datasets → Acute lymphoblastic leukemia landscape →

Download

Direct links to NCBI, no account and no request form: the whole study as GSE27237_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 118 samples.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗

Also filed as BioProject PRJNA170829. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 23334668) ↗

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 118 more — browse all 118 samples with per-sample file links →

Similar datasets

GSE7965 Blood and Adipose tissue samples 1722 samples
GSE20142 Primary human leucocyte RNA expression of unrelated Dutch individuals. 1240 samples
GSE194040 I-SPY2-990 mRNA/RPPA Data Resource: mRNA component 988 samples
GSE36133 Expression data from the Cancer Cell Line Encyclopedia (CCLE) 917 samples
GSE37069 Gene response to major burn injuries 590 samples
GSE25066 Genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer 508 samples
GSE49710 RNA-Seq reveals an unprecedented complexity of the neuroblastoma transcriptome and is suitable for clinical endpoint prediction [microarray] 498 samples
GSE47729 Global peripheral blood gene expression study 350 samples

Search all human microarray datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.