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Soluble epoxide hydrolase inhibition confers neuroprotective and anti-inflammatory effect in a tauopathy mouse model

GSE272373 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/04/30 Platform GPL24247
Summary
Inhibition of soluble epoxide hydrolase (sEH) has been shown to suppress neuroinflammation through stabilizing epoxy fatty acids. Here we examined the role of sEH inhibitor TPPU in PS19 tauopathy mouse model by treating the 6-month-old wild-type and PS19 mice with vehicle or TPPU via drinking water continuously for 12 weeks, followed by performing single nucleus RNA-sequencing of the hippocampal tissues of the treated mice.
Published in
Inhibition of soluble epoxide hydrolase confers neuroprotection and restores microglial homeostasis in a tauopathy mouse model
Wang S, Qi C, Rajpurohit C et al. · Molecular neurodegeneration 2025 · PMID 40264187 · doi:10.1186/s13024-025-00844-x
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Also filed as BioProject PRJNA1136532 and SRA study SRP520335. Searching any of these in the dataset finder brings you back here.

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