Inflammatory intracellular signaling in neurons is influenced by glial soluble factors in iPSC-based cell model of PARK2-associated Parkinson’s disease

Neuroinflammation is considered one of the driving factors in Parkinson’s disease (PD). Astrocytes affect the function of neurons in different ways, of which humoral interactions are very important. Here, we used neuronal and glial cell cultures differentiated from iPSC of healthy donors (HD) and PD patients with different PARK2 mutations (PD) in order to evaluate the influence of glial secretome on inflammatory gene network in neurons and to estimate the impact of the lack of Parkin to this interaction.