GEO series
Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
GSE272416
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/03/03
GPL21103
Summary
We collected gene expression data (RNAseq) from mature Ly6G+ neutrophils isolated from mice bone marrow. The samples were obtained from both Wild-Type and RAB27A knockout mice. These neutrophils were either treated with CpG, a TLR9 agonist, for 6 hours or left untreated. The transcriptional data complement the study of the role of Rab27a-mediated vesicular trafficking on signaling pathways downstream of TLR9 activation and cytokine secretion in immune cells.
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Paper (PMID 39126651) ↗
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