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Adenosine 5’-tetraphosphate and adenosine triphosphate signaling in THP-1 macrophages.

GSE272546 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/02/21 Platform GPL24676
Summary
The endogenous nucleotide adenosine 5’-tetraphosphate (Ap4) has emerged as a potent vasoconstrictor. Despite its structural similarity to the danger signal adenosine triphosphate (ATP), the immunomodulatory effects of Ap4 remain unclear. To gain a deeper insight into the biological processes underlying Ap4- and ATP-mediated responses, RNA-sequence analysis of transcriptional changes in THP-1 macropahges was performed. After 3 hours of stimulation with Ap4 or ATP, THP-1 macrophages showed significant changes in RNA expression compared to the unstimulated control.
Published in
The vasoconstrictor adenosine 5'-tetraphosphate is a danger signal that induces IL-1β
Bockstiegel J, Engelhardt J, Schuchardt M et al. · Molecular medicine (Cambridge, Mass.) 2025 · PMID 39984847 · doi:10.1186/s10020-025-01116-6
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Also filed as BioProject PRJNA1137324 and SRA study SRP520779. Searching any of these in the dataset finder brings you back here.

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