DNA glycosylases Ogg1 and Mutyh mediate gene expression of PRC2 targets important for memory formation
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 128 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 128 samples: 44 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognitionCellular and molecular life sciences : CMLS · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272603_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1137411 and SRA study SRP520871. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 128 samples.
How we read this: 44 replicated groups read from 128 sample titles; they account for 128 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8406479 BS_WT_Rep1 BS_WT
- GSM8406480 BS_WT_Rep2 BS_WT
- GSM8406481 BS_Mutyh_Rep1 BS_Mutyh
- GSM8406482 BS_Mutyh_Rep2 BS_Mutyh
- GSM8406483 BS_Ogg1_Rep1 BS_Ogg1
- GSM8406484 BS_Ogg1_Rep2 BS_Ogg1
- GSM8406485 BS_DKO_Rep1 BS_DKO
- GSM8406486 BS_DKO_Rep2 BS_DKO
- GSM8406487 ChIP_WT_K4_G1 ChIP_WT_K4_G
- GSM8406488 ChIP_WT_K4_G3 ChIP_WT_K4_G
- GSM8406489 ChIP_WT_K4_G2 ChIP_WT_K4_G
- GSM8406490 ChIP_WT_K27_G1 ChIP_WT_K27_G
- GSM8406491 ChIP_WT_K27_G3 ChIP_WT_K27_G
- GSM8406492 ChIP_WT_K27_G2 ChIP_WT_K27_G
- GSM8406493 ChIP_WT_Suz12_G1 ChIP_WT_Suz12_G
- GSM8406494 ChIP_WT_Suz12_G3 ChIP_WT_Suz12_G
- GSM8406495 ChIP_WT_Suz12_G2 ChIP_WT_Suz12_G
- GSM8406496 ChIP_WT_Input_G1 ChIP_WT_Input_G
- GSM8406497 ChIP_WT_Input_G3 ChIP_WT_Input_G
- GSM8406498 ChIP_WT_Input_G2 ChIP_WT_Input_G
- GSM8406499 ChIP_Mutyh_K4_G1 ChIP_Mutyh_K4_G
- GSM8406500 ChIP_Mutyh_K4_G3 ChIP_Mutyh_K4_G
- GSM8406501 ChIP_Mutyh_K4_G2 ChIP_Mutyh_K4_G
- GSM8406502 ChIP_Mutyh_K27_G1 ChIP_Mutyh_K27_G
- GSM8406503 ChIP_Mutyh_K27_G3 ChIP_Mutyh_K27_G
- GSM8406504 ChIP_Mutyh_K27_G2 ChIP_Mutyh_K27_G
- GSM8406505 ChIP_Mutyh_Suz12_G1 ChIP_Mutyh_Suz12_G
- GSM8406506 ChIP_Mutyh_Suz12_G3 ChIP_Mutyh_Suz12_G
- GSM8406507 ChIP_Mutyh_Suz12_G2 ChIP_Mutyh_Suz12_G
- GSM8406508 ChIP_Mutyh_Input_G1 ChIP_Mutyh_Input_G
- GSM8406509 ChIP_Mutyh_Input_G3 ChIP_Mutyh_Input_G
- GSM8406510 ChIP_Mutyh_Input_G2 ChIP_Mutyh_Input_G
- GSM8406511 ChIP_Ogg1_K4_G1 ChIP_Ogg1_K4_G
- GSM8406512 ChIP_Ogg1_K4_G3 ChIP_Ogg1_K4_G
- GSM8406513 ChIP_Ogg1_K4_G2 ChIP_Ogg1_K4_G
- GSM8406514 ChIP_Ogg1_K27_G1 ChIP_Ogg1_K27_G
- GSM8406515 ChIP_Ogg1_K27_G3 ChIP_Ogg1_K27_G
- GSM8406516 ChIP_Ogg1_K27_G2 ChIP_Ogg1_K27_G
- GSM8406517 ChIP_Ogg1_Suz12_G1 ChIP_Ogg1_Suz12_G
- GSM8406518 ChIP_Ogg1_Suz12_G3 ChIP_Ogg1_Suz12_G
+ 88 more — browse all 128 samples with per-sample file links →
- GSE272601 DNA glycosylases Ogg1 and Mutyh mediate gene expression of PRC2 targets important for memory formation (ChIP-Seq) 96 samples shares ogg1, prc2, glycosylases, important, formation, mediate, targets, memory
- GSE272602 DNA glycosylases Ogg1 and Mutyh mediate gene expression of PRC2 targets important for memory formation (RNA-Seq) 24 samples shares ogg1, prc2, glycosylases, important, formation, mediate, targets, memory
- GSE297309 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [CUT&Tag] 108 samples shares prc2, mediate
- GSE289642 Noncanonical PRC2 chromatin association reveals a key role of EZHIP in intergenerational epigenetic memory transition [ChIP-Seq, Cut & Run] 107 samples shares prc2, memory
- GSE278811 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization [ChIP-Seq] 77 samples shares prc2, mediate
- GSE278534 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization 76 samples shares prc2, mediate
- GSE297094 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [ChIP-seq 2] 73 samples shares prc2, mediate
- GSE289641 Noncanonical PRC2 chromatin association reveals a key role of EZHIP in intergenerational epigenetic memory transition [RNA-Seq] 68 samples shares prc2, memory
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.