EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization
RNA-seq (gene expression) · mouse · 76 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 76 samples: 14 conditions, mostly with about 6 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278534_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1167742 and SRA study SRP536093. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 76 samples.
How we read this: 14 replicated groups read from 76 sample titles; they account for 76 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8548326 oocyte_wt_f_1 oocyte_wt_f
- GSM8548327 oocyte_wt_f_2 oocyte_wt_f
- GSM8548328 oocyte_wt_f_3 oocyte_wt_f
- GSM8548329 oocyte_matKO_f_1 oocyte_matKO_f
- GSM8548330 oocyte_matKO_f_2 oocyte_matKO_f
- GSM8548331 oocyte_matKO_f_3 oocyte_matKO_f
- GSM8548332 oocyte_matKO_f_4 oocyte_matKO_f
- GSM8548333 2C_wt_f_1 2C_wt_f
- GSM8548334 2C_wt_f_2 2C_wt_f
- GSM8548335 2C_wt_f_3 2C_wt_f
- GSM8548336 2C_wt_f_4 2C_wt_f
- GSM8548337 2C_wt_f_5 2C_wt_f
- GSM8548338 2C_wt_m_1 2C_wt_m
- GSM8548339 2C_wt_m_2 2C_wt_m
- GSM8548340 2C_wt_m_3 2C_wt_m
- GSM8548341 2C_wt_m_4 2C_wt_m
- GSM8548342 2C_wt_m_5 2C_wt_m
- GSM8548343 2C_wt_m_6 2C_wt_m
- GSM8548344 2C_matKO_f_1 2C_matKO_f
- GSM8548345 2C_matKO_f_2 2C_matKO_f
- GSM8548346 2C_matKO_f_3 2C_matKO_f
- GSM8548347 2C_matKO_f_4 2C_matKO_f
- GSM8548348 2C_matKO_f_5 2C_matKO_f
- GSM8548349 2C_matKO_f_6 2C_matKO_f
- GSM8548350 2C_matKO_m_1 2C_matKO_m
- GSM8548351 2C_matKO_m_2 2C_matKO_m
- GSM8548352 2C_matKO_m_3 2C_matKO_m
- GSM8548353 2C_matKO_m_4 2C_matKO_m
- GSM8548354 2C_matKO_m_5 2C_matKO_m
- GSM8548355 2C_matKO_m_6 2C_matKO_m
- GSM8548356 blastocyst_wt_f_1 blastocyst_wt_f
- GSM8548357 blastocyst_wt_f_2 blastocyst_wt_f
- GSM8548358 blastocyst_wt_f_3 blastocyst_wt_f
- GSM8548359 blastocyst_wt_f_4 blastocyst_wt_f
- GSM8548360 blastocyst_wt_f_5 blastocyst_wt_f
- GSM8548361 blastocyst_wt_f_6 blastocyst_wt_f
- GSM8548362 blastocyst_wt_m_1 blastocyst_wt_m
- GSM8548363 blastocyst_wt_m_2 blastocyst_wt_m
- GSM8548364 blastocyst_wt_m_3 blastocyst_wt_m
- GSM8548365 blastocyst_wt_m_4 blastocyst_wt_m
+ 36 more — browse all 76 samples with per-sample file links →
- GSE278811 EZHIP-mediated PRC2 inhibition is required to maintain H3K27me3-dependent imprinting post fertilization [ChIP-Seq] 77 samples shares prc2, h3k27me3-dependent, ezhip-mediated, fertilization, inhibition, imprinting, required, maintain
- GSE217538 Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2. 59 samples shares prc2, inhibition
- GSE249591 Gene suppression by PRC2 enhances the gene inductions by Aire and the development of mimetic cell populations 572 samples shares prc2
- GSE289641 Noncanonical PRC2 chromatin association reveals a key role of EZHIP in intergenerational epigenetic memory transition [RNA-Seq] 68 samples shares prc2
- GSE293160 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [RNA-seq] 24 samples shares prc2
- GSE272602 DNA glycosylases Ogg1 and Mutyh mediate gene expression of PRC2 targets important for memory formation (RNA-Seq) 24 samples shares prc2
- GSE291454 A conserved function of EZH2-PRC2 in the repression of primitive endoderm cell fate [RNA-Seq - mouse] 22 samples shares prc2
- GSE263885 Chromatin repression by PRC2 results in reduced gene expression driving key features of CD8 T cell exhaustion [RNA-seq] 20 samples shares prc2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.