Egr2 inhibition of PDGFRα in oligodendrocytes is necessary for resocialization normalizing cooperation defects in early socially isolated mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 × siNC vs 6 × siEgr2Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Oligodendrocyte Egr2 Mediates the Beneficial Effect of Resocialization on the Social Ability of Socially Isolated MiceNeuroscience bulletin · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE272732_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1138467 and SRA study SRP521239. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8409805 siNC_1 siNC
- GSM8409806 siNC_2 siNC
- GSM8409807 siNC_3 siNC
- GSM8409808 siNC_4 siNC
- GSM8409809 siNC_5 siNC
- GSM8409810 siNC_6 siNC
- GSM8409811 siEgr2_1 siEgr2
- GSM8409812 siEgr2_2 siEgr2
- GSM8409813 siEgr2_3 siEgr2
- GSM8409814 siEgr2_4 siEgr2
- GSM8409815 siEgr2_5 siEgr2
- GSM8409816 siEgr2_6 siEgr2
- GSE273333 Cene expression profile at single cell level of skin cells from Pdgfra lineage cells tracing mice 42 samples shares pdgfr
- GSE181086 RNA-seq in wild type and EGR2 knock-out mouse alveolar macrophages upon vehicle and zymosan treatment 22 samples shares egr2
- GSE279532 PdgfrB signaling impairs skeletal muscle regeneration 15 samples shares pdgfr
- GSE273179 Cene expression profile at single cell level of skin cells from Pdgfra lineage cells tracing mice 15 samples shares pdgfr
- GSE287341 Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium [Figure 5] 12 samples shares pdgfr
- GSE263169 PDGFRa signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking (RNA-seq) 12 samples shares pdgfr
- GSE279051 Estrogen signaling in PDGFRα+ cells positively regulates cortical bone metabolism via IGFBP5 in female mice. 12 samples shares pdgfr
- GSE287336 Dynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium [D8] 9 samples shares pdgfr
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.