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RNA sequencing for wild type and shENO1 U937cells.

GSE272844 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/07/30 Platform GPL24676
Summary
We systematically evaluated the expression pattern and function of ENO1 in AML. Knockdown ENO1 significantly inhibited ERK pathway phosphorylation, ERK pathway inhibitors significantly inhibited proliferation, clonal formation, migration and invasion of AML cells in vitro, blocked cell cycle and promoted apoptosis of AML cells, and activators of ERK pathway could reverse the effects of knockdown ENO1 on AML cells. The results showed that knockdown ENO1 inhibited the proliferation and invasion of AML cells in mice by inhibiting the activation of ERK pathway, and induced a significant increase in the overall survival rate of mice. Overall, this study aims to explore the role of ENO1 in the development and progression of AML and its potential mechanism, in order to provide a potential target for the treatment of AML.
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Also filed as BioProject PRJNA1139105 and SRA study SRP521557. Searching any of these in the dataset finder brings you back here.

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