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The lincRNA Pantr1 mediates site-specific chromatin binding of FOXG1 in hippocampal neurons

GSE272852 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/05/21 Platform GPL24247
Summary
Derailed gene expression programs within the developing nervous system, encompassing both transcriptional and posttranscriptional processes, are implicated in diverse neurodevelopmental diseases. One of those debilitating diseases, the FOXG1-syndrome, lacks full understanding of the mechanistic role of its eponymous gene product, FOXG1. While it is known that FOXG1 acts in part at the chromatin by binding to regulative regions, it is unclear what factors control its presence at specific sites. Long non-coding RNAs (lncRNAs) can mediate site-directed transcription factor binding, but their potential role in FOXG1-syndrome has not been described. Here, we show that the lncRNA Pantr1 mediates site specific binding of FOXG1 using FOXG1 ChIP sequencing upon Pantr1 knockdown.
Published in
The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1
Gather F, Rauleac T, Akol I et al. · Nucleic acids research 2025 · PMID 40548942 · doi:10.1093/nar/gkaf539
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Also filed as BioProject PRJNA1139123 and SRA study SRP521593. Searching any of these in the dataset finder brings you back here.

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