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Neutrophil extracellular DNA traps promote neutophils migration and activation by TLR9 signalling in type 2 autoimmune pancreatitis

GSE272893 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/23 Platform GPL29480
Summary
Neutrophil infiltration around the pancreatic ducts has been found to be associated with type 2 autoimmune pancreatitis (AIP). However, the functional role and clinical importance of neutrophils migration on the progress of pancreatitis is not fully understood. Here, we found that neutrophil extracellular traps (NETs) are abundant around the pancreatic duct in type 2 AIP patients. Moreover, we observed the expression of TLR9 is higher in pancreatic ductal epithelial Cells (HPDEC) in type 2 AIP patients than in other pancreatic diseases. TLR9 acts as a NET-DNA receptor on HPDEC that senses extracellular DNA and subsequently activates the NF-κB pathway to attract neutrophils motility and induce NETs formation. In addition, the TLR9 antagonist hydroxychloroquine (HCQ) can effectively inhibit the activation of inflammatory pathways, reduce the migration of neutrophils and block the positive feedback mechanism, which can be used as a potential target drug for the clinical treatment of type 2 AIP.
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Also filed as BioProject PRJNA1139197 and SRA study SRP521712. Searching any of these in the dataset finder brings you back here.

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