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Regulation of adipocyte de-differentiation and subsequent re-differentiation

GSE272938 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/03/05 Platform GPL24247
Summary
We show the presence of de-differentiated fat (DFAT) cells in subcutaneous and visceral adipose depots under different dietary intervention conditions, whose transcriptomes resemble adipocytes with high differentiation potential and late-stage adipose stem and progenitor cells (ASPC). These data uncover the potential of adipocytes to undergo de-differentiation under regular physiological conditions and shed light on its role in life style change-induced weight loss and regain.
Published in
Characterization of subcutaneous and visceral de-differentiated fat cells
Li Y, Zhang H, Ibáñez CF et al. · Molecular metabolism 2025 · PMID 39884650 · doi:10.1016/j.molmet.2025.102105
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Also filed as BioProject PRJNA1139657 and SRA study SRP521867. Searching any of these in the dataset finder brings you back here.

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