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Aberrant Transitional Alveolar Epithelial Cells Promote Pathogenic Activation of Lung Fibroblasts in Preclinical Fibrosis Modeling (scRNAseq)

GSE273122 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/07/25 Platform GPL24247
Summary
CD44+ and CD44- negative Alveolar type 2 cells (AT2) represent distinct populations in lung fibrosis. To charecterize these cells, we isolated CD44+/- AT2s from WT mice and from fibrotic Sftpc muant lungs and performd RNA sequencing no these populations
Published in
Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models
Hoffman ET, Shah A, Barboza WR et al. · Nature communications 2025 · PMID 41027873 · doi:10.1038/s41467-025-63735-1
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Also filed as BioProject PRJNA1140211 and SRA study SRP522233. Searching any of these in the dataset finder brings you back here.

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