GEO series
Gut microbiota drives vitiligo-related oxidative stress in skin via the metabolite Hippuric Acid
GSE273242
Mus musculus
Expression profiling by high throughput sequencing
38 samples
2024/08/21
GPL24247
Summary
Vitiligo is a common autoimmune skin disorder. We constructed an induced vitiligo mouse model and performed bulk-RNA sequencing on the skin and 16S rRNA sequencing of feces from vitiligo mice and uninduced mice. Next, we performed skin bulk-RNA sequencing after treatment using ABX. Lastly, we subjected gut microbe-related metabolite hippuric acid to control mice and performed bulk-RNA sequencing on the skin to observe oxidative stress-related gene expression changes.
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Paper (PMID 40329424) ↗
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