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POSTN secreted from GSCs promotes GSC self-renewal and tumor growth via activation of the αVβ3/PI3K/AKT/β-catenin/FOSL1 pathway [GSCs_RNA-seq]

GSE273252 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/08/01 Platform GPL29480
Summary
Glioblastoma (GBM), classified as a grade 4 glioma, is the most prevalent intrinsic malignancy of the central nervous system. Glioblastoma stem cells (GSCs) are small populations of GBM cells with self-renewal and multilineage differentiation capabilities and are considered responsible for the tumorigenesis and development of GBM. GSCs also exhibit radiation resistance, chemoresistance, and angiogenic and invasive properties, which are correlated with poor outcomes in GBM patients. Therefore, targeting GSCs constitutes a promising approach for treating GBM patients. Our findings revealed that POSTN secreted from GSCs promotes GSC self-renewal and tumor growth via activation of the αVβ3/PI3K/AKT/β-catenin/FOSL1 pathway.
Published in
The dual role of POSTN in maintaining glioblastoma stem cells and the immunosuppressive phenotype of microglia in glioblastoma
Wang H, Yao L, Chen J et al. · Journal of experimental & clinical cancer research : CR 2024 · PMID 39227950 · doi:10.1186/s13046-024-03175-9
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Also filed as BioProject PRJNA1140868 and SRA study SRP522587. Searching any of these in the dataset finder brings you back here.

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