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scRNA-seq of brain glioblastoma sample

GSE273274 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/11 Platform GPL24676
Summary
Proneural-mesenchymal transition (PMT) is a phenotypic alteration and contributes to therapeutic resistance and recurrence of glioblastoma (GBM). Macrophages, as a main infiltrating component of tumor immune microenvironment (TIM), can regulate the biological processes of PMT. However, the mechanisms driving this process remain largely unknown. Here, We performed single-cell RNA sequencing (scRNA-seq) (3V3) and Spatial transcriptomics RNA sequencing(stRNA-seq)(1V1) from tumor core and matching tumor periphery samples to discripe the overall landscape of tumor and nontumor cells in gliomas.
Published in
STAT3-controlled CHI3L1/SPP1 positive feedback loop demonstrates the spatial heterogeneity and immune characteristics of glioblastoma
Yu W, Gui S, Peng L et al. · Developmental cell 2025 · PMID 39933531 · doi:10.1016/j.devcel.2025.01.014
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Direct links to NCBI, no account and no request form: the whole study as GSE273274_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1141154 and SRA study SRP522688. Searching any of these in the dataset finder brings you back here.

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