Enhanced RNAi does not provide efficient innate antiviral immunity in mice in vivo
Non-coding RNA profiling · mouse · 86 samples
- What it is
- Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
- Organism
- Mus musculus (mouse)
- Samples
- 86 samples: 37 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Enhanced RNAi does not provide efficient innate antiviral immunity in miceNucleic acids research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273338_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
Also filed as BioProject PRJNA1141444 and SRA study SRP522837. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 76 samples.
How we read this: 37 replicated groups read from 86 sample titles; they account for 76 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8426608 mESC WT LCMV MOI 0.01 7 mESC WT LCMV MOI 0.01
- GSM8426609 mESC WT LCMV MOI 0.01 8 mESC WT LCMV MOI 0.01
- GSM8426610 mESC WT LCMV MOI 0.01 S10 mESC WT LCMV MOI 0.01 S
- GSM8426611 mESC WT LCMV MOI 0.01 S9 mESC WT LCMV MOI 0.01 S
- GSM8426612 mESC WT LCMV MOI 1 15 mESC WT LCMV MOI 1
- GSM8426613 mESC WT LCMV MOI 1 16 mESC WT LCMV MOI 1
- GSM8426614 mESC DicerDHEL1 LCMV MOI 0.01 10 mESC DicerDHEL1 LCMV MO…
- GSM8426615 mESC DicerDHEL1 LCMV MOI 0.01 9 mESC DicerDHEL1 LCMV MO…
- GSM8426616 mESC DicerDHEL1 LCMV MOI 0.01 S11 mESC DicerDHEL1 LCMV MO…
- GSM8426617 mESC DicerDHEL1 LCMV MOI 0.01 S12 mESC DicerDHEL1 LCMV MO…
- GSM8426618 mESC DicerDHEL1 LCMV MOI 1 19 mESC DicerDHEL1 LCMV MO…
- GSM8426619 mESC DicerDHEL1 LCMV MOI 1 20 mESC DicerDHEL1 LCMV MO…
- GSM8426620 mESC DicerDHEL1 PKRnull LCMV MOI 0.01 11 mESC DicerDHEL1 PKRnull…
- GSM8426621 mESC DicerDHEL1 PKRnull LCMV MOI 0.01 12 mESC DicerDHEL1 PKRnull…
- GSM8426622 mESC DicerDHEL1 PKRnull LCMV MOI 1 23 mESC DicerDHEL1 PKRnull…
- GSM8426623 mESC DicerDHEL1 PKRnull LCMV MOI 1 24 mESC DicerDHEL1 PKRnull…
- GSM8426624 mESC DicerKO LCMV MOI 0.01 1 mESC DicerKO LCMV MOI 0…
- GSM8426625 mESC DicerKO LCMV MOI 0.01 2 mESC DicerKO LCMV MOI 0…
- GSM8426626 mESC DicerS4 LCMV MOI 0.01 1 mESC DicerS4 LCMV MOI 0…
- GSM8426627 mESC DicerS4 LCMV MOI 0.01 2 mESC DicerS4 LCMV MOI 0…
- GSM8426628 mESC DicerS4 LCMV MOI 0.01 S13 mESC DicerS4 LCMV MOI 0…
- GSM8426629 mESC DicerS4 LCMV MOI 0.01 S14 mESC DicerS4 LCMV MOI 0…
- GSM8426630 mESC DicerO3 LCMV MOI 0.01 1 mESC DicerO3 LCMV MOI 0…
- GSM8426631 mESC DicerO3 LCMV MOI 0.01 2 mESC DicerO3 LCMV MOI 0…
- GSM8426632 mESC DicerO3 LCMV MOI 0.01 S15 mESC DicerO3 LCMV MOI 0…
- GSM8426633 mESC DicerO3 LCMV MOI 0.01 S16 mESC DicerO3 LCMV MOI 0…
- GSM8426634 mESC WT MosIR S1 mESC WT MosIR S
- GSM8426635 mESC WT MosIR S2 mESC WT MosIR S
- GSM8426636 mESC DicerDHEL1 MosIR S3 mESC DicerDHEL1 MosIR S
- GSM8426637 mESC DicerDHEL1 MosIR S4 mESC DicerDHEL1 MosIR S
- GSM8426638 mESC DicerS4 MosIR S5 mESC DicerS4 MosIR S
- GSM8426639 mESC DicerS4 MosIR S6 mESC DicerS4 MosIR S
- GSM8426640 mESC Dicer03 MosIR S7 mESC Dicer03 MosIR S
- GSM8426641 mESC Dicer03 MosIR S8 mESC Dicer03 MosIR S
- GSM8426685 mESC WT LCMV MOI 0.01 TrapR S10 mESC WT LCMV MOI 0.01 T…
- GSM8426688 mESC WT LCMV MOI 0.01 TrapR S9 mESC WT LCMV MOI 0.01 T…
- GSM8426689 mESC DicerDHEL1 LCMV MOI 0.01 TrapR S11 mESC DicerDHEL1 LCMV MO…
- GSM8426690 mESC DicerDHEL1 LCMV MOI 0.01 TrapR S12 mESC DicerDHEL1 LCMV MO…
- GSM8426691 mESC DicerS4 LCMV MOI 0.01 TrapR S13 mESC DicerS4 LCMV MOI 0…
- GSM8426692 mESC DicerS4 LCMV MOI 0.01 TrapR S14 mESC DicerS4 LCMV MOI 0…
+ 46 more — browse all 86 samples with per-sample file links →
- GSE313112 Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity [RNA-Seq MC38] 69 samples shares immunity, innate
- GSE288114 Krüppel-like factor 2 programs early exhausted T cell states and restrains antiviral immunity [RNA-Seq] 32 samples shares antiviral, immunity
- GSE299495 Maternal Helminths Rewire the Microbiota to Promote Offspring Antiviral Immunity via Indole-3-Propionic Acid 28 samples shares antiviral, immunity
- GSE300933 Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells 23 samples shares antiviral, immunity
- GSE256409 Antibody Fc-receptor common gamma chain FcεR1γ stabilizes cell surface receptors in group 3 innate lymphoid cells and promotes anti-infection immunity 20 samples shares immunity, innate
- GSE222745 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [scRNA-Seq] 422 samples shares enhanced
- GSE271800 Diploid embryo complementation of embryonic stem cells efficiently generates a homozygous Gjb2 mutant deaf mouse model 131 samples shares efficient
- GSE248866 The outcomes of caloric restriction are driven by enhanced glucocorticoid rhythms. 114 samples shares enhanced
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.